Many primary care health professionals feel uncomfortable screening for depression and suicide. The reasons are varied. Some do not feel adequately trained to address mental health issues, others feel these issues are overly complex as well as time and labor intensive within the context of a busy primary care practice. Our four presenters, representing the fields of psychiatry, psychology, and social work, will offer easily implemented screening tools and practices that will help flag patients at high risk for depression and suicide and recommend how to efficiently manage and refer them to the appropriate level of care. As completed suicides climb in the United States, particularly among youth, the elderly, and minority populations, the primary care provider may be the best professional able to identify those at high risk of suicide, especially in light of the finding that most people who complete suicide visited their primary care professional within three to six months of their death. Asking about depression and suicide in primary care can save lives!