As clinical trials progress in the United States, the potential for psychedelic-assisted psychotherapy for various indications to become an approved prescription treatment looks increasingly promising. Clinicians interested in new treatment options for mood, anxiety, and substance use disorders can learn the basics on psychedelic-assisted therapy treatment elements and the current state of the research. This information will be presented to help clinicians consider how psychedelic-assisted psychotherapy might be used in the future to serve their patient populations and highlight key ethical considerations in this area.