This presentation will help clinicians optimize both patient mindset ("set") and treatment environment ("setting") to improve psychiatric outcomes through recognition of the impact of expectancy effects and therapeutic alliance. Application of “set” and “setting” principles to psychopharmacology will help clinicians improve adherence, leverage placebo effects and reduce nocebo effects. Ultimately, this presentation aims to shift the focus away from "what" treatments are delivered to "how" they are implemented. By attending, participants will gain actionable strategies to enhance therapeutic outcomes, improve medication adherence, and create supportive settings that foster patient stability and growth.