Suicide is a public health crisis and the leading cause of psychiatry-related death. However, clinicians have limited resources when assessing and treating a patient with suicidal thoughts and behaviors. The presentation will discuss recent advances in the assessment and treatment of suicide risk. Key questions include: Who can be enrolled into research safely and ethically? How can we design clinical trials for the evaluation of rapid changes in suicide risk? What should we target to reduce suicidal thoughts and behaviors? Why do our treatments work?