On Demand Grand Rounds: Engineering Brain Circuits to Treat Psychiatric Disorders
This presentation was originally reviewed on November 14, 2023, and broadcast live online on November 15, 2023, from 12:00 PM – 1:00 PM ET.
The views and opinions expressed by this presenter in this lecture are their own, and do not represent the views of Sheppard Pratt.
Mental disorders arise from brain circuit dysfunctions, but most of our treatments target the whole brain rather than defined circuits. Deep brain stimulation (DBS) is a more circuit-directed approach that has done well in movement disorders but has very mixed results in randomized clinical trials for mental illness. Part of the difficulty is that psychiatric DBS is delivered in a trial-and-error fashion, without clear evidence that it engages the target circuits. I will discuss new strategies for developing biomarkers to guide that target engagement, centered around the idea of understanding how brain stimulation changes cognition and decision-making. We have identified ways in which DBS can augment top-down executive function and have linked those changes to cortical electrophysiology. In animals, we have developed new approaches to understand how those changes occur and how we can leverage them for clinical benefit. Taken together, these offer the prospect of a new generation of rationally designed brain stimulation therapies.
This activity is intended for physicians, nurses, psychologists, social workers, counselors and other mental health professionals.
At the conclusion of this activity, attendees will be able to:
- Identify clinical challenges in invasive neurostimulation for mental disorders.
- Describe the role of fronto-striatal circuits in behavioral flexibility.
- Discuss how a domain-focused approach can be more valuable than a diagnosis-focused approach in understanding mechanisms of brain stimulation.
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Sheppard Pratt regularly hosts renowned speakers from across the country at our headquarters in Towson. We provide educational opportunities on subjects including psychiatric disorders, issues of behavioral health, systems-based change, mental and somatic co-morbidities, psychiatric effects on health and health outcomes, advances in neurobiology, and clinical developments in concepts underlying drug treatment of psychiatric disorders. We are accredited by the Accreditation Council of Continuing Medical Education, the Maryland Nurses’ Association, the Maryland Board of Psychology, the Maryland Board of Social Work, and the National Board of Certified Counselors.
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This activity was provided by a grant from the Substance Abuse and Mental Health Services Administration.
About the speaker
Alik Widge, MD, PhD is a brain stimulation psychiatrist and biomedical engineer. He is an Associate Professor of Psychiatry at the University of Minnesota, where he directs the Translational NeuroEngineering Lab. Dr. Widge completed his MD at the University of Pittsburgh, his PhD in Robotics at Carnegie Mellon University, psychiatry residency at the University of Washington, and fellowships at Massachusetts General Hospital and the Massachusetts Institute of Technology. His research focuses on brain stimulation for severe and treatment-resistant mental illness, with particular emphasis on deep brain stimulation and related implantable technologies. Dr. Widge's recent work has demonstrated new algorithms for closed-loop brain stimulation, stimulation methods for modifying connectivity in the distributed circuits of mental illness, and hardware solutions for embodying those insights. His laboratory studies both rodent models for prototyping these new technologies and human participants to identify biomarkers and targets for future intervention.
Sheppard Pratt holds the standard that its continuing medical education programs should be free of commercial bias and conflict of interest. In accord with Sheppard Pratt's Disclosure Policy, as well as standards of the Accreditation Council for Continuing Medical Education (ACCME) and the American Medical Association (AMA), all planners, reviewers, speakers and persons in control of content have been asked to disclose any relationship he /she has with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months. All planners, reviewers and speakers have also been asked to disclose any payments accepted for this lecture from any entity besides Sheppard Pratt, and if there will be discussion of any products, services, or off-label uses of product(s) during this presentation.
reports he is a consultant for Abbott. He will not discuss any products or off-label uses in this presentation. He will discuss deep brain stimulation in this presentation. All relationships have been mitigated.
Event Planners/Reviewers Disclosures: The following event planners and/or reviewers are reported as having no financial interest, arrangement or affiliation with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months: Todd Peters, MD, Deepak Prabhakar, MD, Elizabeth Ryznar, MD, MSc, Louis Marino, MD, Ehsan Syed, MD, Devi Bhuyan, PhD, Faith Dickerson, PhD, Carrie Etheridge, LCSW-C, Tom Flis, LCPC, Stacey Garnett, RN, MSN, Stephanie M. Robinson, MSN, RN, PMH-BC, NPD-BC, NE-BC , Heather Billings, RN, Lisa Illum, MLIS, MEd, and Jennifer Tornabene.
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- 1.00 ACEP NBCC clock hours
- 1.00 AMA PRA Category 1 Credit™
- 1.00 Category II credits for Social Workers
- 1.00 Psychologists
- 1.00 MNA Contact Hours for Nurses
- 1.00 Participation
ON DEMAND WEBINAR: FOR BEST RESULTS WATCH USING GOOGLE CHROME
Grand Rounds: Engineering Brain Circuits to Treat Psychiatric Disorders
Alik Widge, MD, PhD
Associate Professor of Psychiatry
Director, Translational NeuroEngineering Lab
University of Minnesota
Originally reviewed November 14, 2023.
Originally broadcast live November 15, 2023, from 1:45 PM – 3:15 PM ET
Enduring Activity Credit Expiration Date: December 16, 2025.
Activity Time: One hour webinar lecture with a 15-minute evaluation process. Total Time: 1:15.
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