On Demand Grand Rounds: Precision Treatments And Pharmacogenomics for Depression and Bipolar Illnesses: The Time Has Come

Wolfe Adler Award Lecture

This presentation was re-reviewed on June 5, 2024, and was live in-person on October 16, 2019, from 11:30 AM - 1:00 PM ET.

According to the WHO, depression is the highest burden of disease and is the 2nd most expensive. As a profession, we have made huge transitions and improvements in the treatment of mental illnesses. But we have several key steps to take. This presentation will discuss why the time is now for precision healthcare. One size treatment does not, and will not ever, fit all.

Target Audience

This activity is intended for psychologists, social workers, counselors, and other mental health professionals.

Learning Objectives

After this lecture attendees will be able to:

1. Describe reasons why depression and bipolar disorder illnesses lead world health organization disability ratings for all medical illnesses.
2. List multiple causes for the depressive clinical syndrome (phenotype) that explains why one specific treatment will never effectively treat all causes
3. List key clinical steps all clinicians should use to select and use the optimal precision treatments for each individual with depression and bipolar illness.

Course summary
Available credit: 
  • 1.50 ACEP NBCC clock hours
  • 1.50 Category II credits for Social Workers
  • 1.50 Psychologists
  • 1.50 Participation
Course opens: 
Course expires: 

Sheppard Pratt’s Professional Education Program is pleased to provide Wednesdays at Sheppard Pratt free of charge as a public service to the mental health community.  Your tax-deductible donations will help maintain the outstanding quality of this service. 

Sheppard Pratt is dedicated to improving quality of life through mental health, special education, and addiction services for children, adolescents, adults and older adults.  Our patient-centered treatment approach, combined with our legacy of clinical excellence, sets us apart from other health systems on both a local and national level.  We have been ranked among the nation’s top psychiatric hospitals for 24 consecutive years by U. S. News & World Report.  Founded in 1853 by philanthropist Moses Sheppard, Sheppard Pratt Health System still abides by its Quaker traditions and values.

Sheppard Pratt regularly hosts renowned speakers from across the country at our headquarters in Towson. We provide educational opportunities on subjects including psychiatric disorders, issues of behavioral health, systems-based change, mental and somatic co-morbidities, psychiatric effects on health and health outcomes, advances in neurobiology, and clinical developments in concepts underlying drug treatment of psychiatric disorders. We are accredited by the Accreditation Council of Continuing Medical Education, the Maryland Nurses’ Association, the Maryland Board of Psychology, the Maryland Board of Social Work, and the National Board of Certified Counselors.

Please send your contributions to:

Sheppard Pratt Professional Education Program
Wednesdays Lecture Fund
6501 North Charles Street, Baltimore, Maryland 21204

Professional Education Program: 410.938.4593
Conference Center at Sheppard Pratt: 410.938.3900

There is no commercial support for this activity.

About The Speaker

Dr. John F. Greden is the Rachel Upjohn Professor Emeritus of Psychiatry and Clinical Neurosciences in the Department of Psychiatry, Active Emeritus; Founder of the Frances and Kenneth Eisenberg and Family Depression Center and served as its executive director from 2001-21; Founding Chair, National Network of Depression Centers (NNDC); and Research Professor Emeritus in the Michigan Neurosciences Institute. He joined the faculty at the University of Michigan Medical School in 1974 and served as Chair of the University of Michigan’s Department of Psychiatry from 1985 to 2007, when he stepped down to focus on directing the Depression Center and developing the NNDC.

To address the globe’s huge health burdens, disabilities and costs associated with clinical depressions, bipolar disorders, and related conditions, Dr. Greden proposed establishment of the country’s inaugural Eisenberg Family Depression Center at the University of Michigan. Approved by the Regents in 2001, a new Depression Center-Ambulatory Psychiatry facility opened in 2006. The Eisenberg Family Depression Center integrates research, clinical, educational and public policy efforts of more than 330 members from 13 University Schools and Colleges and 33 different University departments. Dr. Greden subsequently led efforts to establish similar centers throughout the country and integrate them into a National Network of Depression Centers patterned after the National Cancer Center Network. 16 eminent universities signed an NNDC Charter in a ceremony in Ann Arbor in October, 2008 and the NNDC has now grown to 27. Dr. Greden served as the Chair of the National Network of Depression Centers from its foundation until 2014, and now serves as Founding Chair.

Dr. Greden is past-President of the Society of Biological Psychiatry; the Psychiatric Research Society; the American Association of Chairs of Departments of Psychiatry (AACDP); the Academic Psychiatry Consortium; and the Board of Directors of the American Foundation for Suicide Prevention. He edited the Journal of Psychiatric Research for seven years, chaired the Council on Research for the American Psychiatric Association for five years, served as Council Member of the American College of Neuropsychopharmacology (ACNP), Co-Chair of the National Psychiatry Training Council established by NIMH, and was selected as the 2005 recipient of the Distinguished Alumnus Award of the University of Minnesota Medical School. In  2013 the University of Michigan’s Council for Disability Concerns awarded Dr. Greden the James T. Neubacher Award. The American Psychiatric Association recently conveyed the Mrazek keynote Award to him for leading pharmacogenomic research efforts, and American College of Psychiatrists awarded the Mood Disorders Research Award and plenary speaker award for the 2021 meeting, and the Michigan Governor appointed him to a newly established Suicide Prevention Commission, where he serves on the Executive Committee.

Disclosure Statements

Sheppard Pratt holds the standard that its continuing medical education programs should be free of commercial bias and conflict of interest. In accord with Sheppard Pratt's Disclosure Policy, as well as standards of the Accreditation Council for Continuing Medical Education (ACCME) and the American Medical Association (AMA), all planners, reviewers, speakers and persons in control of content have been asked to disclose any relationship he /she has with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months. All planners, reviewers and speakers have also been asked to disclose any payments accepted for this lecture from any entity besides Sheppard Pratt, and if there will be discussion of any products, services or off-label uses of product(s) during this presentation.

John F. Greden, M.D.reports having scientific advisory functions with Janssen Pharmaceutical, Naurex (Allergan) Pharmaceutical, Cerecor Pharmaceutical, NeuralStem, Med-IQ, Inc., College Student Mental Health ConsuSAGE Therapeutics, Pharmacogenomics Study Funded by AssureX and Myriad Neuroscience (I am not a paid consultant or employee), Clarigent (Artificial Intelligence for suicide prevention): pending ltant, during the past 12 months. He will discuss medications, and off-label uses in this presentation. This presentation was initially planned and recorded prior to January 1, 2023; therefore, the financial disclosure statement from the speaker reflects only the preceding 12 months, as was the standard at the time. This enduring activity was last reviewed for content validity on June 5, 2024. All conflicts have been mitigated through review.

Event Planners/Reviewers Disclosures: The following event planners and/or reviewers are reported as having no financial interest, arrangement or affiliation with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months: Todd Peters, MD, Elizabeth Ryznar, MD, MSc, Louis J. Marino, Devi Bhuyan, PsyD, Faith Dickerson, PhD, Carrie Etheridge, LCSW-C, Tom Flis, LCPC, Stacey Garnett, RN, MSN, Stephanie M. Robinson, MSN, RN, PMH-BC, NPD-BC, NE-BC , Heather Billings, RN, Lisa Illum, MLIS, MEd, and Jennifer Tornabene.


Psychologist Statement: Sheppard Pratt is authorized by the State Board of Examiners of Psychologists as a sponsor of continuing education. Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this continuing education activity.  Sheppard Pratt designates this educational activity for a maximum of 1.5 contact hours for Psychologists.

Social Worker Statement: Sheppard Pratt is authorized by the Board of Social Work Examiners of Maryland to offer continuing education for Social Workers.  Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this continuing education activity. This activity is approved for 1.5 contact hours in Category II credits for Social Workers.

Counselor Statement:  Sheppard Pratt has been approved by NBCC as an Approved Continuing Education Provider, ACEP No. 5098.  Programs that do not qualify for NBCC credit are clearly identified.  Sheppard Pratt is solely responsible for all aspects of the program.  This activity is available for 1.5 NBCC clock hours.

Available Credit

  • 1.50 ACEP NBCC clock hours
  • 1.50 Category II credits for Social Workers
  • 1.50 Psychologists
  • 1.50 Participation
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Grand Rounds: Precision Treatments And Pharmacogenomics for Depression and Bipolar Illnesses: The Time Has Come

John Greden, MD

Founder, Frances and Kenneth Eisenberg and Family Depression Center

Rachel Upjohn Professor Emeritus of Psychiatry and Clinical Neurosciences

Research Professor Emeritus, Michigan Neuroscience Institute

Founding Chair, National Network of Depression Centers

Chair Emeritus, University of Michigan Department of Psychiatry

Ann Arbor, MI

Re-reviewed on June 5, 2024.
Originally broadcast live October 16, 2019, from 11:30 AM - 1:00 PM ET
Enduring Activity Credit Expiration Date: June 3, 2026.

Activity Time: One and a half-hour recorded webinar lecture with a 15-minute evaluation process. Total Time: 1:45

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There is no commercial support for this activity.

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