Plastics production and use has grown exponentially since its commercial introduction in the 1950s. Although it has produced many societal benefits, the large-scale and indiscriminate use of plastics, especially in the last few decades, has led to large-scale environmental and health problems. Two findings raise significant neuropsychiatric concerns: micro- and nanoplastics are present in human brains and plastics-related endocrine-disrupting chemicals can cross the placenta and the blood-brain barrier. This talk will provide an overview of the plastics crisis and its relevance to mental health.