Despite growing evidence that placebo effects significantly impact outcomes in both pain and mental health treatment, clinicians often underutilize these mechanisms in everyday practice. This gap persists due to limited education on the neurobiology of placebo responses and how to ethically integrate expectancy, patient-clinician interaction, and learning history into care. This presentation addresses this clinical blind spot by translating laboratory-based discoveries into actionable clinical strategies. Attendees will gain practical tools to recognize and leverage placebo mechanisms to enhance therapeutic response, particularly in chronic pain and mental health contexts, leading to more informed, personalized, and effective patient care.