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Placebo Effects: From Laboratory Mechanistic Research to Clinical Research
This presentation will be an ONLINE VIRTUAL LIVE broadcast on July 2, 2025, from 12:00 pm - 1:00 pm ET. While this activity is LIVE and can only be viewed during the time specified, the evaluation will be available online until July 30, 2025. Go to the Register tab above to learn how to participate for continuing education credit, watch the broadcast and download the slides.
The views and opinions expressed by this presenter in this lecture are their own, and do not represent the views of Sheppard Pratt.
Despite growing evidence that placebo effects significantly impact outcomes in both pain and mental health treatment, clinicians often underutilize these mechanisms in everyday practice. This gap persists due to limited education on the neurobiology of placebo responses and how to ethically integrate expectancy, patient-clinician interaction, and learning history into care. This presentation addresses this clinical blind spot by translating laboratory-based discoveries into actionable clinical strategies. Attendees will gain practical tools to recognize and leverage placebo mechanisms to enhance therapeutic response, particularly in chronic pain and mental health contexts, leading to more informed, personalized, and effective patient care.
Target Audience
This activity is intended for physicians, nurses, psychologists, social workers, and other mental health professionals.
Learning Objectives
At the conclusion of this activity, attendees will be able to:
- Define the neurobiological mechanisms that underlie placebo effects in pain and mental health conditions.
- Explain how prior therapeutic experience and patient expectations influence the magnitude and persistence of placebo responses.
- Apply communication strategies to ethically enhance placebo responses in clinical practice.
Sheppard Pratt’s Professional Education Program is pleased to provide Wednesdays at Sheppard Pratt free of charge as a public service to the mental health community. Your tax-deductible donations will help maintain the outstanding quality of this service.
Sheppard Pratt is dedicated to improving quality of life through mental health, special education, and addiction services for children, adolescents, adults and older adults. Our patient-centered treatment approach, combined with our legacy of clinical excellence, sets us apart from other health systems on both a local and national level. We have been ranked among the nation’s top psychiatric hospitals for 24 consecutive years by U. S. News & World Report. Founded in 1853 by philanthropist Moses Sheppard, Sheppard Pratt Health System still abides by its Quaker traditions and values.
Sheppard Pratt regularly hosts renowned speakers from across the country at our headquarters in Towson. We provide educational opportunities on subjects including psychiatric disorders, issues of behavioral health, systems-based change, mental and somatic co-morbidities, psychiatric effects on health and health outcomes, advances in neurobiology, and clinical developments in concepts underlying drug treatment of psychiatric disorders. We are accredited by the Accreditation Council of Continuing Medical Education, the Maryland Nurses’ Association, the Maryland Board of Psychology, the Maryland Board of Social Work, and the National Board of Certified Counselors.
Please send your contributions to:
Sheppard Pratt Professional Education Program
Grand Rounds Fund
6501 North Charles Street, Baltimore, Maryland 21204
Professional Education Program: 410.938.4593
Conference Center at Sheppard Pratt: 410.938.3900
There is no commercial support for this activity.
About the speaker
Dr. Luana Colloca is an MPower Distinguished Professor at the University of Maryland, Baltimore, and the Director of the Placebo Beyond Opinion Center at the University of Maryland School of Nursing. Dr. Colloca holds an MD, a Master’s degree in Bioethics, and a PhD in Neuroscience. She completed her postdoctoral training at the Karolinska Institute in Stockholm, Sweden, and a senior research fellowship at the National Institutes of Health in Bethesda, USA.
Dr. Colloca has conducted studies on the behavioral, neural, and pharmacological mechanisms of pain modulation related to placebo and nocebo effects. Her lab has also developed an interest in virtual reality as a non-pharmacological approach to relieving pain and other symptoms. She has published in top-ranked international journals. Her research has been cited over 20,000 times (H-index 66).
Disclosure Statements
Sheppard Pratt holds the standard that its continuing medical education programs should be free of commercial bias and conflict of interest. In accord with Sheppard Pratt's Disclosure Policy, as well as standards of the Accreditation Council for Continuing Medical Education (ACCME) and the American Medical Association (AMA), all planners, reviewers, speakers and persons in control of content have been asked to disclose any relationship he /she has with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months. All planners, reviewers and speakers have also been asked to disclose any payments accepted for this lecture from any entity besides Sheppard Pratt, and if there will be discussion of any products, services, or off-label uses of product(s) during this presentation.
Luana Colloca, MD, PhD, MS, reports that she is a consultant for Metz, Cognitvita, Veterans Health Administration, and an advisor for Vertex. She also reports receiving royalties from Great Learning River and Oxford Press. She will not discuss any products, services, or off-label uses in this presentation. All relationships have been mitigated through review.
Event Planners/Reviewers Disclosures: The following event planners and/or reviewers are reported as having no financial interest, arrangement or affiliation with any entity producing, marketing, selling, re-selling, or distributing health care goods or services consumed by, or used on, patients, during the past 24 months: Todd Peters, MD, Michael C. Hann, MD, MBA, Ronald Means, MD, Rajeev Krishna, MD, PhD, MBA, Louis Marino, MD, Devi Bhuyan, PsyD, Faith Dickerson, PhD, Carrie Etheridge, LCSW-C, Tom Flis, LCPC, Paula Bostwick, MSN, RN, CENP, Alfredo Sagisi, DNP, MS, RN, FACHE, Maggie O'Neill MSN, RN, PMH-BC, Lisa Illum, MLIS, MEd, and Jennifer Tornabene.
Physician Statement: Sheppard Pratt is accredited by The Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this CME activity. Sheppard Pratt designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurse Statement: Sheppard Pratt is approved as a provider of nursing continuing professional development by the Maryland Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this CME activity. This activity provides 1.0 contact hour for nurses.
Psychologist Statement: Sheppard Pratt is authorized by the State Board of Examiners of Psychologists as a sponsor of continuing education. Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this CE activity. Sheppard Pratt designates this educational activity for a maximum of 1.0 contact hour for Psychologists.
Social Worker Statement: Sheppard Pratt is authorized by the Board of Social Work Examiners of Maryland to offer continuing education for Social Workers. Sheppard Pratt takes responsibility for the content, quality, and scientific integrity of this CE activity. This activity is approved for 1.0 contact hour in Category I credits for Social Workers.
Counselor Statement: No NBCC credit available.
Available Credit
- 1.00 AMA PRA Category 1 Credit™
- 1.00 Category I credits for Social Workers
- 1.00 Psychologists
- 1.00 MNA Contact Hours for Nurses
- 1.00 Participation
This presentation will be an ONLINE VIRTUAL LIVE broadcast on July 2, 2025, from 12:00 pm - 1:00 pm ET. While this activity is LIVE and can only be viewed during the time specified, the evaluation will be available online until July 30, 2025. Go to the Register tab above to learn how to participate for continuing education credit, watch the broadcast and download the slides.
The codeword will be announced during the live event. The codeword is used to prove you attended the event. You will not need it to access the broadcast.
The broadcast can not be accessed through cme.sheppardpratt.org. You will need to use the link provided below to watch the broadcast.
Attending the broadcast is not the only requirement to earn credit for attending. Continue reading below to see the rest of the requirements for credit.
EARN CONTINUING EDUCATION CREDIT FOR YOUR ATTENDANCE
PRIOR TO THE EVENT: Log into your Sheppard Pratt Ethos account and register by taking the Pretest. Select the activity by series, title or speaker name. Go to the last tab, REGISTER and select the GREEN RECTANGLE, TAKE COURSE, and follow the prompts. Complete the Pretest and select attendance and you will be registered for this activity. You will not be able to work further until you are marked attended by entering the codeword. You do not need the codeword to watch the live broadcast. The link for the broadcast is located on the Register/Take Course tab of the course page.
REGISTER TO WATCH THE BROADCAST: There is a separate registration that you must complete to attend the live broadcast. Click on the Registration link located in the Register/Take Course tab. Enter your first name, last name, and email address. You will receive a confirmation email that you have registered to attend the broadcast. When it is time for the live broadcast, you can use the link in the confirmation email or click on the registration link again. Only when you have pre-registered, can you click on the Already Registered button and enter the email address you registered under to enter the broadcast. The link to watch the broadcast will be LIVE at 11:30 am ET.
https://onlinexperiences.com/Launch/QReg/ShowUUID=C193AD7B-A2BA-4552-9C00-9FA7EF85FCEA
DOWNLOAD THE HANDOUT.
Use this link to download the handout. This handout will be available for download on Tuesday, July 1, 2025, at 12:00 pm ET.
https://drive.google.com/file/d/1lfECIEtbsc42kb845BGcJkHT7-GXxmZK/view?usp=sharing
DURING THE EVENT: Because you will view this event online, there will not be a sign in sheet. Instead of signing in, a codeword will be given during the lecture for you. The codeword will be announced during the live broadcast. There are two ways to enter the codeword: by text/SMS & through the website. To use the website to enter the codeword to be marked attended, you will go to https://cme.sheppardpratt.org/code and enter the codeword there. To use SMS to enter the codeword, you will text the codeword to 410-291-8061. To save time, add this phone number to your contacts. Once you enter the codeword, you can click on the Pending Courses tab and you will see the course listed there. From this tab you will be able to complete your course.
**A note regarding entering the codeword. Our codeword process is open for almost 4 weeks. Due to rising attendance numbers at our events, our website is more prone to experience high volumes and slow down as a result. It is recommended that you wait to enter the codeword and log back into the website after the broadcast is over to avoid any issues. If you notice the system is slow, please try again later.**
AFTER THE LECTURE: Once you enter the codeword, you can click on the Pending Courses tab and you will see the course listed there. From this tab you will be able to complete your course. Select the last tab, TAKE COURSE, and select the GREEN RECTANGLE, TAKE COURSE and follow the prompts. Please use the navigation button located in the lower right corner to continue throughout the course for best results. Complete the evaluation and credit designation to earn continuing education hours or credits. You must complete each component of the COURSE PROGRESS BAR to earn credit for the activity. Your transcript will reflect all completed events.
Questions? Please look at our FAQ page https://cme.sheppardpratt.org/content/faq or email [email protected].
Required Hardware/software
Optimal System Configuration
Flash Player: Adobe Flash Player 10.1+
Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+
Operating System: Windows XP+ or Mac OS X 10.4+
Internet Connection: 1 Mbps or higher
Minimum Requirements
Windows PC: 500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera
Macintosh: Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit
Hardware/Software Specifications
This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player.